Antioxidant Activities of The Brown Seaweed Sargassum: Narrative Review
Aktivitas Antioksidan Rumput Laut Cokelat Sargassum: Naratif Review
DOI: https://doi.org/10.22487/jiagrisains.v26i3.2025.163-174
Keywords:
ABTS, DPPH, FRAP, senyawa bioaktif, senyawa fenolikAbstract
Rumput laut cokelat Sargassum merupakan rumput laut yang telah banyak dimanfaatkan untuk produk pangan maupun non pangan. Sargassum memiliki kandungan senyawa bioaktif yang tinggi dan beragam. Sargassum memiliki berbagai macam bioaktivitas terutama antioksidan. Review artikel ini bertujuan untuk menyusun and merangkum data terbaru mengenai senyawa bioaktif dan antioksidan rumput laut Sargassum. Review artikel menggunakan artikel penelitian yang bersumber dari referensi ilmiah ScienceDirect terbitan tahun 2020–2025. Kandungan senyawa bioaktif dari berbagai spesies rumput laut Sargassum, yakni senyawa fenolik (flavonoid, fenol), alkaloid, steroid, terpenoid, saponin, glikosida kardiak, mycosporine-like amino acids, dan pigmen (fukosantin, flobatanin, klorofil-a, klorofil-d, α-karoten, β-karoten, xantofil, fikobiliprotein, dan karotenoid). Senyawa bioaktif utama rumput laut Sargassum, yakni senyawa fenolik (0,09791–521,84 mg GAE/g). Sargassum menunjukkan adanya aktivitas antioksidan pada berbagai metode pengujian (DPPH, FRAP, dan ABTS). Persentase inhibisi aktivitas antioksidan Sargassum berdasarkan metode DPPH berkisar 0,18–89,84% dan ABTS berkisar 64,018–93,94%. Aktivitas antioksidan Sargassum dipengaruhi oleh kandungan senyawa bioaktif, metode ekstraksi, konsentrasi ekstrak, spesies, dan lokasi sampel. Kandungan senyawa fenolik dan aktivitas antioksidan Sargassum berpotensi untuk digunakan dalam pangan fungsional, kemasan, kosmetik, dan farmasi.
References
Afrin, F., Ahsan, T., Mondal, M. N., Rasul, M. G., Afrin, M., Silva, A. A., Yuan, C., & Shah, A. K. M. A. (2023). Evaluation of antioxidant and antibacterial activities of some selected seaweeds from Saint Martin’s Island of Bangladesh. Food Chemistry Advances, 3, 100393. https://doi.org/10.1016/j.focha.2023.100393
Ahmed, N., Mohamed, H. F., Xu, C., Sun, X., & Huang, L. (2022). Novel antibacterial activity of Sargassum fusiforme extract against coral white band disease. Electronic Journal of Biotechnology, 57, 12–23. https://doi.org/10.1016/j.ejbt.2022.03.002
Al-Hashdy, D. F., El-Shaibany, A., Abdelkhalek, A. S., Raweh, S. M., Elaasser, M. M., & Raslan, A. E. (2025). Phytochemical profiling, toxicity, and pharmacological investigations of the brown seaweed Sargassum vulgare collected from the Red Sea coast combined with molecular docking analysis and SwissADMET prediction. South African Journal of Botany, 182, 165–184. https://doi.org/10.1016/j.sajb.2025.05.006
Al-Mur, B. A., & Alsiary, W. A. (2025). Bioactivities related to pigments content of Sargassum sp. Collected from Jeddah coast, Saudi Arabia, Red Sea. Egyptian Journal of Aquatic Research, 51(2), 181–188. https://doi.org/10.1016/j.ejar.2025.02.001
Alreshidi, M., Badraoui, R., Adnan, M., Patel, M., Alotaibi, A., Saeed, M., Ghandourah, M., Al-Motair, K. A., Arif, I. A., Albulaihed, Y., & Snoussi, M. (2023). Phytochemical profiling, antibacterial, and antibiofilm activities of Sargassum sp. (brown algae) from the Red Sea: ADMET prediction and molecular docking analysis. Algal Research, 69. https://doi.org/10.1016/j.algal.2022.102912
Bahrami, S., Nateghi, L., Rashidi, L., Nobandegani, B. K., & Ghorbanpour, M. (2025). Evaluation of the properties of polysaccharides extracted from brown macroalgae (Sargassum ilicifolium) by methods of conventional, microwave, and subcritical water extraction. Innovative Food Science & Emerging Technologies, 102, 103975. https://doi.org/10.1016/j.ifset.2025.103975
Balasubramaniam, V., June Chelyn, L., Vimala, S., Mohd Fairulnizal, M. N., Brownlee, I. A., & Amin, I. (2020). Carotenoid composition and antioxidant potential of Eucheuma denticulatum, Sargassum polycystum and Caulerpa lentillifera. Heliyon, 6(8). https://doi.org/10.1016/j.heliyon.2020.e04654
Bourgonje, A. R., Feelisch, M., Faber, K. N., Pasch, A., Dijkstra, G., & van Goor, H. (2020). Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease. In Trends in Molecular Medicine (Vol. 26, Issue 11, pp. 1034–1046). Elsevier Ltd. https://doi.org/10.1016/j.molmed.2020.06.006
Budiyanto, F., Sari, M., Widyaningrum, S. R., Putra, A. B. N., Palupi, K. D., Rachman, F., Untari, F., Handayani, T., & Rasyid, A. (2025). Profiling and antiproliferative activity of tropical seaweed extracts using LC-HRMS and in silico approaches. Algal Research, 90, 104181. https://doi.org/10.1016/j.algal.2025.104181
Çerçi, N. A., Aydın, B., Naz, M., Sayın, S., Aytar, E. C., Akküçük, Ş., & Kılıç, A. O. (2025). Development and evaluation of an alginate-based cream formulation from Sargassum vulgare: Antimicrobial, antioxidant, and safety assessments. Algal Research, 90, 104110. https://doi.org/10.1016/j.algal.2025.104110
Chin, Y. Y., Chang, K. A., Ng, W. M., Eng, Z. P., Chew, L. Y., Neo, Y. P., Yan, S. W., Wong, C. L., Kong, K. W., & Ismail, A. (2023). A comparative evaluation of nutritional composition and antioxidant properties of six Malaysian edible seaweeds. Food Chemistry Advances, 3, 100426. https://doi.org/10.1016/j.focha.2023.100426
Cholaraj, R., & Venkatachalam, R. (2024). Investigation of antioxidant and anticancer potential of fucoidan (in-vitro & in-silico) from brown seaweed Padina boergesenii. Algal Research, 79. https://doi.org/10.1016/j.algal.2024.103442
Deepak, P., Perumal, P., Balakrishnan, R., Balasubramanian, B., & Velmurugan, P. (2024). Assessment of antioxidant and digestive enzyme inhibition by phyco-molecules isolated from marine brown alga Sargassum wightii. Food and Humanity, 2. https://doi.org/10.1016/j.foohum.2024.100226
Dip, Md. R. R., Sobuj, M. K. A., Islam, Md. S., Akter, A., Hasan, Md. M., Tasnim, N., Haque, Md. A., & Rafiquzzaman, S. M. (2024). Phytochemicals, antioxidant and antibacterial activity of crude extract of Sargassum polycystum collected from Bangladesh. Food and Humanity, 2, 100278. https://doi.org/10.1016/j.foohum.2024.100278
Ellamie, A. M., Fouda, W. A., Ibrahim, W. M., & Ramadan, G. (2020). Dietary supplementation of brown seaweed (Sargassum latifolium) alleviates the environmental heat stress-induced toxicity in male Barki sheep (Ovis aries). Journal of Thermal Biology, 89. https://doi.org/10.1016/j.jtherbio.2020.102561
Emu, S. A., Dulal, Md. A., Kali, T. Das, Chadni, M. S., Rasul, Md. G., Mondal, Md. N., Ahsan, Md. E., Khan, M., & Shah, A. K. M. A. (2023). Effects of extracting solvents on phytochemical, antioxidant, and antibacterial activity of some seaweeds from the Bay of Bengal offshore Island. Food and Humanity, 1, 1157–1166. https://doi.org/10.1016/j.foohum.2023.09.005
Faisal, S., Almutairi, A. W., Saif, I., Ting, L., Wang, Q., Mustafa, A., & Ebaid, R. (2025). Seaweed valorization as anaerobic co-substrate with fat, oil, and grease: Biomethane potential and microbial dynamics. Bioresource Technology, 421. https://doi.org/10.1016/j.biortech.2025.132155
Farvin, K. H. S., & Jacobsen, C. (2013). Phenolic compounds and antioxidant activities of selected species of seaweeds from Danish coast. Food Chemistry, 138(2–3), 1670–1681. https://doi.org/10.1016/j.foodchem.2012.10.078
Geun Lee, H., Jayawardena, T. U., Liyanage, N. M., Song, K.-M., Choi, Y.-S., Jeon, Y.-J., & Kang, M.-C. (2022). Antioxidant potential of low molecular weight fucoidans from Sargassum autumnale against H2O2-induced oxidative stress in vitro and in zebrafish models based on molecular weight changes. Food Chemistry, 384, 132591. https://doi.org/10.1016/j.foodchem.2022.132591
Goksen, G. (2023). Elucidation and quantification health-promoting phenolic compounds, antioxidant properties and sugar levels of ultrasound assisted extraction, aroma compositions and amino acids profiles of macroalgae, Laurencia papillosa. Ultrasonics Sonochemistry, 98, 106527. https://doi.org/10.1016/j.ultsonch.2023.106527
González-Portela, R. E., Romero-Villegas, G. I., Kapoore, R. V., Alammari, Z. M., Malibari, R. A., Shaikhi, A. Al, Al Hafedh, Y., Aljahdali, A. H., Banjar, R. E., Mhedhbi, E., Filimban, A., Padri, M., & Fuentes-Grünewald, C. (2024). Cultivation of Limnospira maxima under extreme environmental conditions in Saudi Arabia: Salinity adaptation and scaling-up from laboratory culture to large-scale production. Bioresource Technology, 406. https://doi.org/10.1016/j.biortech.2024.131089
Grina, F., Ullah, Z., Kaplaner, E., Moujahid, A., Eddoha, R., Nasser, B., Terzioğlu, P., Yilmaz, M. A., Ertaş, A., Öztürk, M., & Essamadi, A. (2020). In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds. South African Journal of Botany, 128, 152–160. https://doi.org/10.1016/j.sajb.2019.10.021
Gunathilake, T., Akanbi, T. O., Wang, B., & Barrow, C. J. (2024). Antioxidant benefits of Ecklonia radiata algae phenolic extracts in food grade omega-3 delivery systems. Future Foods, 10, 100406. https://doi.org/10.1016/j.fufo.2024.100406
Hu, P., Shi, Q., Wen, Z., Wang, J., & Qin, C. (2024). Potential effects of Sargassum kjellmanianum as a dietary supplement on the growth performance, immunity response, antioxidant status, and ammonia resistance of yellow catfish (Pelteobagrus fulvidraco). Aquaculture Reports, 36. https://doi.org/10.1016/j.aqrep.2024.102181
Huang, L., Lee, J. Y., Park, Y. K., & Lee, J. (2025). Heavy metals in seaweed: Implications for health benefits, risks, and safety regulations. Journal of Agriculture and Food Research, 21. https://doi.org/10.1016/j.jafr.2025.101830
Imchen, T., Tripathi, K, Ramakrishnan, R., & Akshay, K. (2024). Evaluation of the proximate composition and antioxidant capacity of some seaweeds from the Konkan coast of India. Algal Research, 83, 103730. https://doi.org/10.1016/j.algal.2024.103730
Imran, M., Iqbal, A., AL-Huqail, A. A., Suliman Alghanem, S. M., Badshah, S. L., Alghamdi, S., Almehmadi, M., Balgith Algopishi, U., Ali, B., Sohni, S., Ammar Javed, M., & Eldin Darwish, D. B. (2024). Biochemical and nutritional analysis of seaweed (Iyengaria stellata) and its therapeutic significance, using antioxidant, antimicrobial, and hypoglycemic activities. South African Journal of Botany, 171, 695–709. https://doi.org/10.1016/j.sajb.2024.06.002
Jang, H., Lee, J., Park, Y. K., & Lee, J. Y. (2024). Exploring the health benefits and concerns of brown seaweed consumption: A comprehensive review of bioactive compounds in brown seaweed and its potential therapeutic effects. Journal of Agriculture and Food Research, 17. https://doi.org/10.1016/j.jafr.2024.101215
Kim, H. J., Herath, K. H. I. N. M., Dinh, D. T. T., Kim, H. S., Jeon, Y. J., Kim, H. J., & Jee, Y. (2021). Sargassum horneri ethanol extract containing polyphenols attenuates PM-induced oxidative stress via ROS scavenging and transition metal chelation. Journal of Functional Foods, 79. https://doi.org/10.1016/j.jff.2021.104401
Landa-Cansigno, C., Serviere-Zaragoza, E., Morales-Martínez, T. K., Ascacio-Valdes, J. A., Morreeuw, Z. P., Gauyat, C., Stiger-Pouvreau, V., & Reyes, A. G. (2023). The antioxidant and anti-elastase activity of the brown seaweed Sargassum horridum (Fucales, Phaeophyceae) and their early phenolics and saponins profiling for green cosmetic applications. Algal Research, 75, 103271. https://doi.org/10.1016/j.algal.2023.103271
Murdiono, W. E., Razak, N. A. A., Halmi, M. I. E., Yong, J. W. H., & Mahmud, K. (2025). Optimization of aqueous extraction of phenolic compounds and bioactive profiles from brown (Sargassum polycystum) and red (Kappaphycus alvarezii) seaweeds using the response surface method. Algal Research, 86, 103924. https://doi.org/10.1016/j.algal.2025.103924
Nagarajan, D., Oktarina, N., Chen, P. T., Chen, C. Y., Lee, D. J., & Chang, J. S. (2022). Fermentative lactic acid production from seaweed hydrolysate using Lactobacillus sp. And Weissella sp. Bioresource Technology, 344(Pt A), 126166. https://doi.org/10.1016/j.biortech.2021.126166
Perumal, P., Aravinth, A., Dhanasundaram, S., Rajaram, R., Santhanam, P., Palanisamy, M., & James, R. A. (2023). Phytochemical, amino acid and fatty acid profile of selected brown and red seaweed species from Gulf of Mannar, Southeast India. Food and Humanity, 1, 1659–1669. https://doi.org/10.1016/j.foohum.2023.11.015
Pliego-Cortés, H., Bedoux, G., Boulho, R., Taupin, L., Freile-Pelegrín, Y., Bourgougnon, N., & Robledo, D. (2019). Stress tolerance and photoadaptation to solar radiation in Rhodymenia pseudopalmata (Rhodophyta) through mycosporine-like amino acids, phenolic compounds, and pigments in an Integrated Multi-Trophic Aquaculture system. Algal Research, 41. https://doi.org/10.1016/j.algal.2019.101542
Rajauria, G., Ravindran, R., Garcia-Vaquero, M., Rai, D. K., Sweeney, T., & O’Doherty, J. (2021). Molecular characteristics and antioxidant activity of laminarin extracted from the seaweed species Laminaria hyperborea, using hydrothermal-assisted extraction and a multi-step purification procedure. Food Hydrocolloids, 112. https://doi.org/10.1016/j.foodhyd.2020.106332
Santos, J. M., Jesus, B. C., Ribeiro, H., Martins, A., Marto, J., Fitas, M., Pinto, P., Alves, C., Silva, J., Pedrosa, R., & Marrucho, I. M. (2024). Extraction of macroalgae phenolic compounds for cosmetic application using eutectic solvents. Algal Research, 79. https://doi.org/10.1016/j.algal.2024.103438
Sapatinha, M., Oliveira, A., Costa, S., Pedro, S., Gonçalves, A., Mendes, R., Bandarra, N. M., & Pires, C. (2022). Red and brown seaweeds extracts: A source of biologically active compounds. Food Chemistry, 393. https://doi.org/10.1016/j.foodchem.2022.133453
Sekhavatizadeh, S. S., Ganje, M., Hashemi, S. S., & Mozafarian, M. R. (2025). Encapsulation of bioactive compounds from Sargassum ilicifolium: Influence of wall material type and loading content on the physicochemical and structural properties of microparticles. Heliyon, 11(1). https://doi.org/10.1016/j.heliyon.2025.e41652
Sobuj, M. K. A., Shemul, M. S., Islam, Md. S., Islam, Md. A., Mely, S. S., Ayon, M. H., Pranto, S. M., Alam, M. S., Bhuiyan, M. S., & Rafiquzzaman, S. M. (2024). Qualitative and quantitative phytochemical analysis of brown seaweed Sargassum polycystum collected from Bangladesh with its antioxidant activity determination. Food Chemistry Advances, 4, 100565. https://doi.org/10.1016/j.focha.2023.100565
Subbiah, V., Duan, X., Agar, O. T., Dunshea, F. R., Barrow, C. J., & Suleria, H. A. R. (2023). Comparative study on the effect of different drying techniques on phenolic compounds in Australian beach-cast brown seaweeds. Algal Research, 72. https://doi.org/10.1016/j.algal.2023.103140
Tagliapietra, B. L., Salvador-Reyes, R., Pinto, C. C., de Souza, S. M., Pallone, J. A. L., de Araújo Bezerra, J., Moreira Mar, J., Aparecido Sanches, E., & Clerici, M. T. P. S. (2024). Nutritional and techno-functional properties of the brown seaweed Sargassum filipendula. Food Research International, 191, 114728. https://doi.org/10.1016/j.foodres.2024.114728
Ullah, Md. R., Haque, M. A., Hasan, Md. M., Islam, Md. A., & Bhadra, A. (2025). The influences of different drying procedures on the nutritional contents and antioxidant activities of brown seaweed, Sargassum oligocystum Mont. (Sargassaceae). Applied Food Research, 5(2), 101055. https://doi.org/10.1016/j.afres.2025.101055
Urrea-Victoria, V., Furlan, C. M., dos Santos, D. Y. A. C., & Chow, F. (2022). Antioxidant potential of two Brazilian seaweeds in response to temperature: Pyropia spiralis (red alga) and Sargassum stenophyllum (brown alga). Journal of Experimental Marine Biology and Ecology, 549, 151706. https://doi.org/10.1016/j.jembe.2022.151706
War Naw, S., Darli Kyaw Zaw, N., Siti Aminah, N., Amin Alamsjah, M., Novi Kristanti, A., Nege, A. S., & Thanda Aung, H. (2020). Bioactivities, heavy metal contents and toxicity effect of macroalgae from two sites in Madura, Indonesia. Journal of the Saudi Society of Agricultural Sciences, 19(8), 528–537. https://doi.org/10.1016/j.jssas.2020.09.007
Yang, Y., Zhang, M., Alalawy, A. I., Almutairi, F. M., Al-Duais, M. A., Wang, J., & Salama, E. S. (2021). Identification and characterization of marine seaweeds for biocompounds production. Environmental Technology and Innovation, 24. https://doi.org/10.1016/j.eti.2021.101848
Yusof, Z., Lim, V., Khong, N. M. H., Choo, W. S., & Foo, S. C. (2025). Unveiling fucoxanthin’s fate: In vitro Gastrointestinal Digestion Effects on Bioaccessibility, Antioxidant Potential, Colour Changes, and Metabolite Profiles. Food Chemistry, 463. https://doi.org/10.1016/j.foodchem.2024.141209
Zhao, T., Dong, Q., Zhou, H., & Yang, H. (2022). Drying Kinetics, Physicochemical Properties, Antioxidant Activity and Antidiabetic Potential of Sargassum Fusiforme Processed Under Four Drying Techniques. LWT, 163, 113578. https://doi.org/10.1016/j.lwt.2022.113578
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